2020,Vol. 17(3): 268-274
临床实践
潜在不适当用药对老年人不良健康结局影响的系统评价
迟俊婷,牛晓丹,阮海慧,陶红霞,张静,王艳红(
)
730000 兰州市 兰州大学护理学院
The relationship between potentially inappropriate medications use and adverse health outcomes in the older adults：a systematic review
CHI Jun-ting,NIU Xiao-dan,RUAN Hai-hui,TAO Hong-xia,ZHANG Jing,WANG Yan-hong(
)
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摘要： 目的 明确潜在不适当用药对老年人不良健康结局的影响,为预防不良健康结局提供依据。方法 检索PubMed、The Cochrane Library、Web of Science、EMBASE、中国生物医学文献数据库、中国知网和万方数据库,搜集建库至2019年2月关于潜在不适当用药对老年人不良健康结局影响的文献,采用RevMan 5.3软件进行分析。结果 共纳入33项队列研究,结果显示潜在不适当用药对药物不良反应、再次入院率有影响（RR=1.69,95%CI=1.28~2.23,P＜0.001;RR=1.47,95%CI=1.30~1.66,P＜0.001）,但不会增加死亡率（RR=1.02,95%CI=0.98~1.07,P=0.310）。结论 潜在不适当用药是老年人发生药物不良反应/药物不良事件和再次入院的危险因素,增加了社会经济负担,耗费了医疗资源。
关键词： 老年人,
结果评价（卫生保健）,
潜在不适当用药,
系统评价
Abstract: Objective To know the effects of potentially inappropriate medications use on adverse health outcomes in the older adults. Methods The main databases including PubMed,the Cochrane Library,Web of Science,EMBASE,Chinese biomedical literature database,CNKI and WanFang databases were searched from the inception of the database to February 2019. The studies related to inappropriate medications on adverse health outcomes in the older adults were included. Meta-analysis was conducted with RevMan 5.3 software. Results A total of 33 cohort studies were included. The results showed that potentially inappropriate medications use had a significant impact on adverse drug reactions and readmission rates（RR=1.69,95%CI=1.28~2.23,P＜0.001;RR=1.47,95%CI=1.30~1.66,P＜0.001）,but it did not increase mortality（RR=1.02,95%CI=0.98~1.07,P=0.310）. Conclusion Potentially inappropriate medications use is a risk factor for adverse drug reactions and re-hospital admissions in older adults which increases the social and economic burdens.
Key words: Aged,
Outcome Assessment（Health Care）,
Potential inappropriate medications use,
Systematic review
收稿日期: 2019-10-11
基金资助: 国家自然科学基金(71804064);中央高校基本科研业务费专项资金(lzujbky-2017-16)
作者简介: 迟俊婷,女,本科（硕士在读）,护士,E-mail： chijt18@lzu.edu.cn
